Research chemicalResearch chemicalPsychedelicTryptamine

AET (Alpha-ethyltryptamine)

Also known as AET · Monase · Alpha-ethyltryptamine

Written by enwyReviewed 15 Jul 20261 sources0 comments

Alpha-ethyltryptamine (AET) is the alpha-ethyl homologue of AMT. Like AMT it was marketed as an antidepressant (Monase) in the early 1960s before being withdrawn. It has stimulant, entactogenic, and mild psychedelic effects and monoamine oxidase inhibitory activity. It was withdrawn partly due to reports of agranulocytosis and later placed in US Schedule I.

01 Overview

AET was briefly sold as the antidepressant Monase but was withdrawn after cases of agranulocytosis (a dangerous drop in white blood cells) emerged. It shares the alpha-alkyl tryptamine profile of AMT: monoamine release, MAOI activity, and a long duration, with effects described as more stimulant and entactogenic than classically psychedelic.

The MAOI activity carries the same interaction hazards as AMT, and the historical association with agranulocytosis is a distinctive concern. AET was placed in US Schedule I in 1994.

02 Mechanism

Monoamine releaser and reuptake inhibitor with reversible monoamine oxidase inhibition and some serotonin receptor activity; the alpha-ethyl group slows metabolism and prolongs effects.

03 Dosing

Tier	Dose	Route	Notes
Light	40–80 mg	Oral	Anecdotal; stimulant-leaning.
Common	80–150 mg	Oral	Anecdotal; entactogenic and stimulant effects, long duration.

04 Effects

Effect	Magnitude	Evidence
Stimulant / entactogenic effectsEnergising and emotionally opening effects reported by users.	Variable	Anecdotal
Mild psychedeliaPerceptual effects milder than classic psychedelics per reports.	Dose-dependent	Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
Serotonin toxicity from interactionsMAOI activity makes serotonergic drug combinations dangerous.	Severe	Unknown	Observational
AgranulocytosisSevere drop in white blood cells reported during its use as Monase, contributing to withdrawal.	Life-threatening	Rare but documented	Clinical

06 Legal status

United States

Schedule I controlled

Placed in Schedule I in 1994. · as of Jan 2026

07 References

Alpha-ethyltryptamine (Monase): pharmacology and agranulocytosisHistorical clinical literature

08 Discussion0 comments

Create account

Discussion is moderated. No sourcing, vendor names or price talk — those comments are removed, and repeat posts are banned.

This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.