SARMNon-steroidalOralSARM

ACP-105

Also known as ACP105

Written by enwyReviewed 15 Jul 20261 sources0 comments

ACP-105 is a non-steroidal SARM characterised only in preclinical studies, including work on muscle, bone and cognition in animals. There is no human data, so all claims are preclinical or anecdotal. It is expected to share the SARM class profile of testosterone suppression and lipid changes and is unapproved and prohibited in sport.

01 Overview

ACP-105 is a potent non-steroidal androgen-receptor modulator studied in rodents, where it showed anabolic effects on muscle and bone and, in some models, cognitive effects. It has been detected in doping-control research, reflecting its circulation as a research chemical.

No clinical trials exist, so its human efficacy and safety are unknown. Recreational dosing is extrapolated from anecdote. As an androgen-receptor agonist it is expected to suppress endogenous testosterone and alter lipids, consistent with the broader SARM class.

02 Mechanism

Potent non-steroidal androgen-receptor partial agonist with tissue-selective anabolic activity in animal models.

03 Dosing

Tier	Dose	Route	Notes
Light	5–10 mg/day	Oral	Anecdotal only; no validated human dose.
Common	10–20 mg/day	Oral	Higher anecdotal range; risks poorly characterised.

Ester comparison

Ester	Half-life	Injection freq.	Testosterone by mass

04 Effects

Effect	Magnitude	Evidence
Increased muscle and bone massAnimal studies show anabolic effects on muscle and bone.		Preclinical
Possible cognitive effectsSome rodent studies report effects on cognition; unproven and uncharacterised in humans.		Preclinical
Strength and recompositionUsers report gains; no human trials support this.		Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence
Lipid changes (HDL reduction)Reported HDL reductions consistent with the SARM class.	Mild	Common	Anecdotal
Testosterone suppressionExpected suppression of endogenous testosterone from androgen-receptor agonism; not quantified in humans.	Moderate	Common	Anecdotal
Unknown human safety profileNo human data exist to characterise safety.	Moderate	Unknown	Unconfirmed

06 Legal status

United Kingdom

Not licensed as a medicine

as of Jan 2026

United States

Not FDA-approved; unlawful as dietary supplement

as of Jan 2026

07 References

ACP-105 preclinical characterisation and doping detectionPubMed

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.