SARMOralSARMAndrogen receptor modulator

AC-186

Also known as AC-186 · AC186

Written by enwyReviewed 15 Jul 20261 sources0 comments

AC-186 is a non-steroidal selective androgen receptor modulator studied preclinically for neuroprotective and anabolic effects, including in models of spinal cord injury and neuromuscular function. It has been characterised as tissue-selective in animals but has no published human trials.

01 Overview

AC-186 is a SARM investigated largely outside the mainstream muscle-wasting programmes, with preclinical interest in the nervous system as well as muscle. Studies in animal models examined its effects on motor neurons and muscle in the context of injury and neurodegeneration, exploiting the androgen receptor's presence in neural tissue.

As with most tool-compound SARMs, its profile in humans is unknown. Its selectivity and any anabolic benefit are inferred from rodent work, and it appears in the literature and occasionally on research-chemical listings rather than in any clinical setting.

02 Mechanism

A non-steroidal selective androgen receptor modulator that activates androgen receptors in muscle and neural tissue with relative selectivity, studied for combined anabolic and neuroprotective effects in animals.

03 Dosing

Tier	Dose	Route	Notes
Preclinical only	0 mg/day	Oral	No validated human dosing; animal studies only.

Ester comparison

Ester	Half-life	Injection freq.	Testosterone by mass

04 Effects

Effect	Magnitude	Evidence
Neuroprotective effectsShowed protective effects on motor neurons in injury/neurodegeneration models.	Animal models	Preclinical
Muscle-supportive activityAndrogen receptor activation supported muscle in animal studies.	Preclinical	Preclinical

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
Presumed hormonal suppressionAndrogen receptor agonism would be expected to suppress endogenous testosterone; not documented in humans.	Moderate	Unknown	Unconfirmed
Unknown human safety profileNo clinical safety data exist.	Moderate	Unknown	Unconfirmed

06 Legal status

United States

Not approved; research chemical

Preclinical SARM, not marketed. Prohibited in sport by WADA (S1.2). · as of Jan 2026

07 References

Neuroprotective and anabolic actions of the selective androgen receptor modulator AC-186Preclinical neuroscience/pharmacology reports

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.