5-MeO-MET
5-MeO-MET (5-methoxy-N-methyl-N-ethyltryptamine) is a synthetic tryptamine research chemical combining a 5-methoxy group with asymmetric N-methyl/N-ethyl substitution. It is a member of the 5-methoxy tryptamine family and is reported to be shorter-acting and milder than many relatives. Human data are limited to anecdote with no controlled studies.
01 Overview
5-MeO-MET sits within the 5-methoxy tryptamine group that includes 5-MeO-DMT, 5-MeO-MiPT, and 5-MeO-DET. Anecdotal accounts describe a comparatively mild, shorter psychedelic experience with some entactogenic character. Its pharmacology has not been formally studied in humans.
As with other grey-market 5-methoxy tryptamines, dosing, metabolism, and safety are poorly defined, and caution around serotonergic drug interactions is warranted given the family's activity.
02 Mechanism
Presumed serotonin 5-HT2A receptor agonist typical of 5-methoxy tryptamines; not formally characterised in humans.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Light | 10–20 mg | Oral | Anecdotal; no validated dosing. |
| Common | 20–40 mg | Oral | Anecdotal range only. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Mild psychedeliaComparatively gentle psychedelic effects reported by users. | Dose-dependent | Anecdotal | |
| Entactogenic characterSome emotional openness reported; unverified. | Variable | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaGastrointestinal upset reported by some users. | Mild | Unknown | Anecdotal | |
| AnxietyAnxiety at higher doses per user reports. | Moderate | Unknown | Anecdotal |