Research chemicalResearch chemicalPsychedelicTryptamine

5-MeO-DiPT (Foxy)

Also known as Foxy · Foxy Methoxy · 5-methoxy-N,N-diisopropyltryptamine

Written by enwyReviewed 4 Aug 20262 sources0 comments

5-MeO-DiPT (5-methoxy-N,N-diisopropyltryptamine, Foxy or Foxy Methoxy) is a synthetic psychedelic tryptamine described by Shulgin. It is used non-medically for psychedelic, tactile and sensory effects. Human data are anecdotal plus a handful of case reports; potency and safety are poorly characterised, with wide individual dose variation.

01 Overview

5-MeO-DiPT, known as Foxy, is a 5-methoxy tryptamine producing a psychedelic state with strong body and tactile effects, sensory enhancement and variable visuals. It became a widely encountered research chemical in the 2000s and is one of the better-known novel tryptamines, appearing in forensic and toxicology case reports.

Controlled human pharmacology is lacking; most information is anecdotal, supplemented by case reports of intoxication. Reported dose responses vary widely, and adverse effects including nausea, GI upset, anxiety and sympathomimetic effects are common. It was scheduled in the US in 2004.

02 Mechanism

Serotonin receptor agonist acting at 5-HT2A and other subtypes, with 5-HT1A activity characteristic of 5-methoxy tryptamines.

03 Dosing

Tier	Dose	Route	Notes
Threshold	4–6 mg	Oral	Approximate; from user reports.
Common	6–12 mg	Oral	Onset ~20-45 min, duration ~3-6 h. Not clinically validated.
Strong	12–20 mg	Oral	Higher risk of nausea and overwhelming effects.

04 Effects

Effect	Magnitude	Evidence
Tactile / body effectsStrong physical and tactile sensations characterise the experience.		Anecdotal
Sensory and auditory enhancementEnhanced music and sensory perception commonly reported.		Anecdotal
Mood alterationEuphoria or, at times, dysphoria and emotional variability reported.		Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence
Nausea and GI upsetNausea, diarrhoea and abdominal discomfort are frequently reported.	Moderate	Very common	Anecdotal
Anxiety / challenging experienceAnxiety, agitation or panic, more likely at high doses.	Moderate	Common at higher doses	Anecdotal
Cardiovascular stimulationTachycardia and hypertension reported in case reports of intoxication.	Moderate	Common	Observational

06 Legal status

United Kingdom

Class A

Controlled as a tryptamine. · as of Jan 2026

United States

Schedule I

Placed in Schedule I in 2004. · as of Jan 2026

07 References

5-MeO-DiPT (Foxy): toxicology and case reportsJournal of Analytical Toxicology / PubMed

TiHKAL: The ContinuationShulgin & Shulgin, 1997

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.