Research chemicalPsychedelicTryptamineSerotonergic5-Methoxytryptamine
5-MeO-DET (N,N-Diethyl-5-methoxytryptamine)
Also known as 5-Methoxy-DET · N,N-Diethyl-5-methoxytryptamine
5-MeO-DET is the 5-methoxy diethyl tryptamine, an analog of 5-MeO-DMT. It is a psychedelic research chemical reported to be milder and longer than 5-MeO-DMT. No formal human data exists.
01 Overview
5-MeO-DET adds a 5-methoxy group to DET, placing it in the 5-methoxytryptamine family alongside 5-MeO-DMT and 5-MeO-DiPT. It is a rare research chemical.
Users report a psychedelic experience generally described as less overwhelming than 5-MeO-DMT. There is no controlled pharmacology or toxicology, so dosing and safety information is anecdotal.
02 Mechanism
Serotonin receptor agonist with activity at 5-HT2A and 5-HT1A, typical of 5-methoxytryptamines.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Light (reported) | 5–15 mg | Insufflated | Anecdotal. |
| Common (reported) | 15–40 mg | Oral | Anecdotal. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psychedelic perceptual changeAltered perception and cognition reported, milder than 5-MeO-DMT. | moderate | Anecdotal | |
| Body and mood effectsPhysical and emotional shifts described anecdotally. | variable | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Nausea and body loadPhysical discomfort common to 5-methoxytryptamines. | Moderate | Common | Anecdotal | |
| Cardiovascular stimulationRaised heart rate and blood pressure reported, common to 5-MeO tryptamines. | Moderate | Common | Anecdotal |
06 Legal status
United Kingdom
Class A (tryptamine generic clause)
as of Jan 2026
United States
Possibly Analogue Act
as of Jan 2026
07 References
Shulgin A, Shulgin A. TIHKAL: The Continuation (5-methoxytryptamines)Transform Press, 1997
08 Discussion0 comments
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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.