Research chemicalResearch chemicalPsychedelicTryptamine

5-MeO-AMT

Also known as 5-Methoxy-alpha-methyltryptamine · Alpha-O

Written by enwyReviewed 15 Jul 20261 sources0 comments

5-MeO-AMT (5-methoxy-alpha-methyltryptamine) is a potent, long-acting synthetic tryptamine. It combines the alpha-methyl group (which confers stimulant and MAOI-like properties and metabolic resistance) with a 5-methoxy group. It is active at very small oral doses, has a narrow margin between active and toxic doses, and has been linked to serious poisonings and deaths.

01 Overview

5-MeO-AMT is structurally related to both alpha-methyltryptamine (AMT) and the 5-methoxy tryptamines. Its alpha-methyl substitution slows metabolism, producing an extended duration often reported at 12-18 hours or more, and confers monoamine-releasing and monoamine oxidase inhibitory activity. It is exceptionally potent, active in the low single-milligram range, which makes accurate dosing difficult and overdose easy.

The narrow margin between an active and a dangerous dose is the central safety concern. Combined with its long duration and MAOI activity, small dosing errors or interactions with serotonergic drugs can produce severe serotonin toxicity. Fatal and near-fatal cases have been reported. It should be regarded as one of the higher-risk research-chemical tryptamines.

02 Mechanism

Serotonin 5-HT2A receptor agonist with additional monoamine-releasing and reversible monoamine oxidase inhibitory activity; the alpha-methyl group slows metabolism and extends duration.

03 Dosing

Tier	Dose	Route	Notes
Threshold	0.5–1 mg	Oral	Active in the low milligram range; extreme potency makes accurate measurement critical.
Common	2–4 mg	Oral	Anecdotal; narrow margin to toxic doses. Very long duration.

04 Effects

Effect	Magnitude	Evidence
Long-duration psychedeliaProlonged psychedelic and stimulant effects reported by users.	12-18+ hours	Anecdotal
StimulationAmphetamine-like stimulation attributed to the alpha-methyl group.	Marked	Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence
Prolonged tachycardia and hypertensionSustained cardiovascular stimulation over the long duration of effect.	Severe	Unknown	Anecdotal
Serotonin toxicityHyperthermia, agitation, clonus, and autonomic instability, especially with overdose or serotonergic drug combinations. Fatalities reported.	Life-threatening	Reported in poisonings	Observational
Overdose from misdosingThe narrow margin between active and toxic doses makes accidental overdose likely with imprecise measurement.	Life-threatening	Unknown	Observational

06 Legal status

United States

Not explicitly scheduled federally

Not federally scheduled by name but potentially covered by the Federal Analogue Act; banned in several other countries. · as of Jan 2026

07 References

Fatal intoxication involving 5-MeO-AMTJournal of Analytical Toxicology / forensic case reports

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.