Research chemicalResearch chemicalEntactogenBenzofuran

5-APB

Also known as 5-(2-aminopropyl)benzofuran · Benzofury (component)

Written by enwyReviewed 4 Aug 20262 sources0 comments

5-APB is a benzofuran positional isomer of 6-APB and a serotonin-norepinephrine-dopamine releasing agent producing MDMA-like entactogenic effects. It circulated alongside 6-APB in 'Benzofury' products. Human evidence is confined to user reports and toxicological case data.

01 Overview

5-APB (5-(2-aminopropyl)benzofuran) is closely related to 5-APDB and MDA, differing only in ring position from 6-APB. It appeared on the research-chemical market around 2010-2011.

There are no controlled clinical studies. Effect and harm profiles are inferred from user self-reports, analytically confirmed intoxications and its structural similarity to MDA. 5-HT2B agonism is described in vitro, raising the same theoretical valvulopathy concern as 6-APB.

02 Mechanism

Releases serotonin, norepinephrine and dopamine and acts as an agonist at 5-HT2 receptors, including 5-HT2B.

03 Dosing

Tier	Dose	Route	Notes
Light	40–70 mg	Oral	User-reported only.
Common	70–100 mg	Oral	Slightly stronger and more stimulating than 6-APB per reports.
Strong	100–130 mg	Oral	Marked hyperthermia and cardiovascular risk.

04 Effects

Effect	Magnitude	Evidence
Entactogenic empathyMDMA-like emotional warmth and sociability.		Anecdotal
Stimulation and euphoriaEnergetic, euphoric state; more stimulating than 6-APB per user reports.		Anecdotal
Mild psychedelic qualityPerceptual and cognitive shifts reported at higher doses.		Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence
HyperthermiaOverheating in intoxications, aggravated by dancing and warm venues.	Severe	Common at higher doses	Observational
Cardiovascular strainTachycardia and hypertension; 5-HT2B agonism gives theoretical valvular risk.	Severe	Common	Observational
Serotonin toxicityReported features include agitation, clonus and autonomic instability.	Life-threatening	Uncommon; higher with serotonergic drugs	Observational

06 Legal status

United Kingdom

Class B (Misuse of Drugs Act)

Controlled since 2014. · as of Jan 2026

United States

Not federally scheduled

Possible Federal Analogue Act coverage. · as of Jan 2026

07 References

Benzofurans: a new class of new psychoactive substancesEUDA (EMCDDA) drug profile

5-APB toxicology and pharmacologyPubMed search

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.