4-HO-MPT
4-HO-MPT (4-hydroxy-N-methyl-N-propyltryptamine) is a lesser-known synthetic tryptamine psychedelic and a close structural relative of psilocin, differing by asymmetric N-methyl/N-propyl substitution. It exists almost entirely in the grey-market research chemical space with only scattered anecdotal reports and essentially no formal human data.
01 Overview
4-HO-MPT belongs to the family of 4-hydroxy tryptamines that includes psilocin, 4-HO-MET, and 4-HO-DET. Its mixed N-alkyl substitution places it structurally between the shorter and longer 4-hydroxy homologues. Anecdotal reports describe a psilocin-like psychedelic profile of moderate duration.
There are no controlled studies, no validated pharmacokinetics, and no established safety margins. It should be regarded as poorly characterised.
02 Mechanism
Presumed serotonin 5-HT2A receptor agonist, consistent with other 4-hydroxy tryptamine psychedelics; not formally studied in humans.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Light | 5–12 mg | Oral | Anecdotal; no validated dosing. |
| Common | 12–25 mg | Oral | Anecdotal range only. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psilocin-like psychedeliaVisual and cognitive effects resembling psilocin, per limited reports. | Dose-dependent | Anecdotal | |
| Visual distortionColour enhancement and geometric visuals reported anecdotally. | Variable | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaGastrointestinal upset reported by some users. | Mild | Unknown | Anecdotal | |
| AnxietyAnxiety reported at higher doses. | Moderate | Unknown | Anecdotal |