4-HO-MiPT (Miprocin)
4-HO-MiPT (4-hydroxy-N-methyl-N-isopropyltryptamine, Miprocin) is a synthetic psilocin-analogue psychedelic tryptamine described by Shulgin. It is taken non-medically for visual and entheogenic effects. Human evidence is anecdotal; potency and safety are not established, and individual dose responses differ markedly.
01 Overview
4-HO-MiPT is a 4-hydroxytryptamine related to psilocin, differing by an N-isopropyl substitution. Users describe a bright, stimulating psychedelic state with strong visuals and comparatively clear headspace, and a moderate duration. It is sold as a research chemical in jurisdictions where classical psychedelics are controlled.
No controlled human studies exist; all effect and dose information comes from self-experiment reports and harm-reduction sources. Reported potency is high (active in low-milligram amounts), so accurate weighing matters and dose responses vary widely between people. Serotonergic psychedelics carry a risk of acute psychological distress and, rarely, prolonged perceptual disturbances.
02 Mechanism
Serotonin 5-HT2A receptor agonist/partial agonist, the classical psychedelic mechanism, with activity at additional serotonin receptor subtypes.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 5–10 mg | Oral | Approximate; from user reports. |
| Common | 15–25 mg | Oral | Onset ~20-40 min, duration ~4-6 h. Not clinically validated. |
| Strong | 25–35 mg | Oral | Overwhelming effects more likely. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Visual effectsPronounced open- and closed-eye visuals, colour and geometry enhancement reported by users. | Anecdotal | ||
| Stimulation and euphoriaEnergetic, mood-lifting quality is a commonly noted feature. | Anecdotal | ||
| Altered thought and perceptionChanges in cognition, time sense and self-perception typical of psychedelics. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Stimulation / insomniaRestlessness and difficulty sleeping, reflecting the stimulating character. | Mild | Common | Anecdotal | |
| Cardiovascular stimulationIncreased heart rate and blood pressure. | Mild | Common | Anecdotal | |
| Anxiety and challenging experiencesFear, confusion or panic, more likely at high doses or in poor setting. | Moderate | Common at higher doses | Anecdotal |