Research chemicalPsychedelicTryptamineSerotonergicPsilocin analog
4-HO-EPT (N-Ethyl-N-propyl analog)
Also known as 4-Hydroxy-EPT · 4-Hydroxy-N-ethyl-N-propyltryptamine
4-HO-EPT is the 4-hydroxy N-ethyl-N-propyl psilocin analog, an obscure psychedelic tryptamine sold as a research chemical. It reportedly gives a psilocybin-like experience. No formal human data exists.
01 Overview
4-HO-EPT extends the psilocin analog series with ethyl and propyl groups on the terminal nitrogen. Like other 4-hydroxy tryptamines it is presumed orally active without an MAOI.
The compound has no published pharmacology or safety data. Reported effects resemble psilocybin, but all dosing and risk information is anecdotal and uncertain.
02 Mechanism
Presumed serotonin 5-HT2A receptor agonist, as with psilocin and its analogs.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Light (reported) | 8–15 mg | Oral | Anecdotal. |
| Common (reported) | 15–30 mg | Oral | Anecdotal. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psilocybin-like psychedeliaVisuals and cognitive change resembling psilocybin, per self-reports. | moderate | Anecdotal | |
| Mood elevationEuphoria or emotional openness reported. | variable | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaOnset nausea common to oral tryptamines. | Mild | Common | Anecdotal | |
| AnxietyDifficult experiences at higher doses. | Moderate | Common | Anecdotal |
06 Legal status
United Kingdom
Class A (tryptamine generic clause)
as of Jan 2026
United States
Possibly Analogue Act
as of Jan 2026
07 References
Shulgin A, Shulgin A. TIHKAL: The Continuation (4-substituted tryptamines)Transform Press, 1997
08 Discussion0 comments
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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.