4-HO-DiPT
4-HO-DiPT (4-hydroxy-N,N-diisopropyltryptamine) is a synthetic tryptamine psychedelic first described by Alexander Shulgin. It is noted anecdotally for an unusually fast onset and short duration compared with most tryptamines. Human data are limited to Shulgin's self-experiments and user reports; there are no controlled clinical studies.
01 Overview
4-HO-DiPT is the 4-hydroxy analogue of DiPT and a positional relative of psilocin, differing in the N,N-diisopropyl substitution. In TiHKAL, Shulgin describes it as one of the faster-acting orally active tryptamines, with effects reportedly beginning within minutes and largely resolving inside two to three hours.
Beyond anecdote there is essentially no formal pharmacology or safety data in humans. It is sold as a grey-market research chemical. Reported effects resemble other 4-substituted tryptamine psychedelics but with a compressed timeline.
02 Mechanism
Presumed serotonin 5-HT2A receptor agonist, as with other 4-hydroxy tryptamine psychedelics; not formally characterised in humans.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Light | 5–10 mg | Oral | Anecdotal; no validated dosing. |
| Common | 15–25 mg | Oral | Anecdotal range from Shulgin and user reports. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Rapid-onset psychedeliaUsers report an unusually fast onset and short duration relative to other tryptamines. | Onset within minutes | Anecdotal | |
| Visual distortionColour enhancement and mild visual effects reported anecdotally. | Dose-dependent | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaGastrointestinal upset reported by some users. | Mild | Unknown | Anecdotal | |
| Anxiety and disorientationFast onset can be jarring and provoke anxiety per user reports. | Moderate | Unknown | Anecdotal |