Research chemicalPsychedelicTryptamineSerotonergicPsilocin analog
4-AcO-EPT (4-Acetoxy-N-ethyl-N-propyltryptamine)
Also known as 4-Acetoxy-EPT · 4-Acetoxy-N-ethyl-N-propyltryptamine
4-AcO-EPT is the 4-acetoxy ester of EPT, presumed to act as a prodrug for 4-HO-EPT. It is an obscure psychedelic research chemical reported to be psilocybin-like. No formal human data exists.
01 Overview
4-AcO-EPT combines the 4-acetoxy prodrug motif with ethyl and propyl N-substituents, filling out the psilocin-analog series. It is presumed to deacetylate to the active 4-HO-EPT.
The compound has no published pharmacology or safety data. Reported effects resemble psilocybin, but all dosing and risk information is anecdotal and carries high uncertainty.
02 Mechanism
Likely a prodrug hydrolysed to 4-HO-EPT, presumed serotonin 5-HT2A receptor agonist.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Light (reported) | 10–20 mg | Oral | Anecdotal. |
| Common (reported) | 20–40 mg | Oral | Anecdotal. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psilocybin-like psychedeliaVisuals and cognitive alteration resembling psilocybin per self-reports. | moderate | Anecdotal | |
| Mood elevationEuphoria or emotional openness reported. | variable | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaOnset nausea common to oral tryptamines. | Mild | Common | Anecdotal | |
| AnxietyDifficult experiences at higher doses. | Moderate | Common | Anecdotal |
06 Legal status
United Kingdom
Class A (tryptamine generic clause)
as of Jan 2026
United States
Possibly Analogue Act
as of Jan 2026
07 References
Shulgin A, Shulgin A. TIHKAL: The Continuation (4-acetoxy tryptamines)Transform Press, 1997
08 Discussion0 comments
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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.