Research chemicalPsychedelicTryptamineSerotonergicPsilocin analog

4-AcO-DET (Ethacetin)

Also known as Ethacetin · 4-Acetoxy-DET · 4-Acetoxy-N,N-diethyltryptamine

Written by enwyReviewed 5 Aug 20261 sources0 comments

4-AcO-DET is the 4-acetoxy ester of DET, thought to act as a prodrug for 4-HO-DET (a psilocin analog). It is an orally active psychedelic tryptamine sold as a research chemical, with effects reported to resemble psilocybin. Human data is anecdotal.

01 Overview

4-AcO-DET (ethacetin) is one of the 4-acetoxy tryptamines developed as psilocybin/psilocin analogs. By analogy to 4-AcO-DMT it is presumed to be deacetylated in the body to the active 4-hydroxy form.

Users report a psilocybin-like psychedelic experience of moderate duration. No formal clinical, pharmacokinetic or toxicological studies have been conducted, so dosing and safety data are anecdotal only.

02 Mechanism

Likely a prodrug hydrolysed to 4-HO-DET, which acts as a serotonin 5-HT2A receptor agonist like psilocin.

03 Dosing

Tier	Dose	Route	Notes
Light	10–20 mg	Oral	Anecdotal.
Common	20–40 mg	Oral	Anecdotal.

04 Effects

Effect	Magnitude	Evidence
Psilocybin-like psychedeliaVisuals, euphoria and altered thought resembling psilocybin mushrooms.	moderate	Anecdotal
Emotional opennessIntrospective, sometimes uplifting mood reported.	variable	Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
NauseaStomach discomfort during onset.	Mild	Common	Anecdotal
AnxietyDifficult or fearful experiences, particularly at higher doses.	Moderate	Common	Anecdotal

06 Legal status

United Kingdom

Class A (tryptamine generic clause)

as of Jan 2026

United States

Possibly Analogue Act

Analog of controlled tryptamines. · as of Jan 2026

07 References

Shulgin A, Shulgin A. TIHKAL: The Continuation (4-substituted tryptamines)Transform Press, 1997

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.