Research chemicalResearch chemicalDissociativeArylcyclohexylamine

3-HO-PCP

Also known as 3-HO-PCP · 3-Hydroxyphencyclidine

Written by enwyReviewed 4 Aug 20262 sources0 comments

3-HO-PCP is a potent arylcyclohexylamine sold as a research chemical that, unusually for the class, has significant opioid receptor activity in addition to NMDA antagonism. This dual action makes it particularly dangerous, adding respiratory-depression and dependence risks not typical of other dissociatives.

01 Overview

3-HO-PCP is a hydroxylated PCP analogue distinguished by its notable agonist activity at the mu-opioid receptor alongside potent NMDA antagonism. This means it combines dissociative effects with opioid effects, including euphoria, sedation and, critically, the potential for respiratory depression.

Human data are limited to anecdote and scattered case reports. Its opioid activity raises the risk of overdose and dependence beyond that of purely dissociative arylcyclohexylamines, and it is regarded within harm-reduction communities as one of the more dangerous compounds in the class.

02 Mechanism

Potent NMDA-receptor antagonist with significant mu-opioid receptor agonist activity, producing combined dissociative and opioid effects.

03 Dosing

Tier	Dose	Route	Notes
Threshold	2–4 mg	Oral
Common	3–8 mg	Insufflated
Common	4–10 mg	Oral	Potent; opioid activity adds overdose risk.

04 Effects

Effect	Magnitude	Evidence
Dissociation with opioid effectsCombined dissociative and opioid-like euphoria and sedation.		Anecdotal
AnalgesiaStrong pain relief from combined NMDA and opioid action.		Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence
Respiratory depressionOpioid agonist activity can suppress breathing, especially in overdose or with other depressants.	Life-threatening	Opioid-mediated, dose-dependent	Anecdotal
Opioid dependencePhysical opioid dependence and withdrawal reported with regular use, unusual for the dissociative class.	Severe	With repeated use	Anecdotal
Overdose (narrow margin)Small active doses and combined mechanisms make overdose easy and dangerous.	Life-threatening	High potency	Anecdotal

06 Legal status

United States

Possibly controlled as a PCP analogue

May fall under the Federal Analogue Act. · as of Jan 2026

United Kingdom

Class B controlled drug

Controlled as an arylcyclohexylamine. · as of Jan 2026

07 References

3-HO-PCP pharmacology and opioid activityPubMed literature

New psychoactive substances: dissociativesEUDA (European Union Drugs Agency)

08 Discussion0 comments

Create account

Discussion is moderated. No sourcing, vendor names or price talk — those comments are removed, and repeat posts are banned.

This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.