Research chemicalPsychedelicThioether2C-T phenethylamine
2C-T-8
Also known as 2,5-dimethoxy-4-(cyclopropylmethylthio)phenethylamine
2C-T-8 is a cyclopropylmethylthio member of the 2C-T sulfur-substituted phenethylamine series. Shulgin reported a clear-headed psychedelic effect at moderate doses, but human use is scarce and no safety data exist.
01 Overview
2C-T-8 carries a cyclopropylmethylthio group at the 4-position of the 2C scaffold. Shulgin described a relatively clean, visual experience of intermediate duration. It sits among many obscure 2C-T variants that never saw wide distribution.
As with the wider 2C-T family, MAOI combinations are considered dangerous and toxicology is absent, so any use is essentially an uncontrolled experiment.
02 Mechanism
Partial agonist at 5-HT2A/2C receptors; the 4-thioether substituent enhances potency relative to oxygen analogues.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Reported common | 30–50 mg | Oral | Shulgin range; duration several hours. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Visual psychedeliaColour enhancement and mild geometry reported as relatively clear-headed. | moderate | Anecdotal | |
| Mood elevationPositive, engaged mood in favourable reports. | moderate | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaGastric upset during onset, common to 2C-T compounds. | Mild | Common | Anecdotal | |
| MAOI interaction risk2C-T thioethers are metabolised by MAO; combining with MAOIs risks hypertensive/serotonergic crisis. | Life-threatening | Rare | Anecdotal |
06 Legal status
United Kingdom
Psychoactive Substances Act 2016
as of Jan 2026
United States
Schedule I (Federal Analogue Act)
Analogue when intended for consumption. · as of Jan 2026
07 References
PiHKAL: A Chemical Love Story (2C-T-8 entry)Shulgin & Shulgin, 1991
08 Discussion0 comments
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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.