Research chemicalPsychedelicThioether2C-T phenethylamine
2C-T-13
Also known as 2,5-dimethoxy-4-(2-methoxyethylthio)phenethylamine
2C-T-13 is a 2-methoxyethylthio 2C-T analogue described by Shulgin as a gentle, insightful psychedelic. It is obscure, rarely encountered, and has no safety data.
01 Overview
2C-T-13 carries a 4-(2-methoxyethylthio) substituent on the 2C phenethylamine core. Shulgin's notes describe a mild, thoughtful effect at moderate doses. It never circulated widely and remains a footnote in the 2C-T series.
As with all 2C-T compounds, MAO-dependent metabolism means MAOI combinations are hazardous, and no toxicology has been performed.
02 Mechanism
Partial agonist at 5-HT2A/2C receptors; the methoxyethylthio group gives moderate potency.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Reported common | 25–40 mg | Oral | Shulgin range. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Gentle psychedeliaSoft visual and cognitive effects described as insightful. | mild-moderate | Anecdotal | |
| RelaxationCalm, contemplative tone in favourable reports. | mild | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaOnset gastric discomfort typical of the class. | Mild | Common | Anecdotal | |
| MAOI interaction riskCombining with MAOIs risks serotonergic/hypertensive crisis. | Life-threatening | Rare | Anecdotal |
06 Legal status
United Kingdom
Psychoactive Substances Act 2016
as of Jan 2026
United States
Schedule I (Federal Analogue Act)
Analogue when intended for consumption. · as of Jan 2026
07 References
PiHKAL: A Chemical Love Story (2C-T-13 entry)Shulgin & Shulgin, 1991
08 Discussion0 comments
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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.