2C-T
2C-T (2,5-dimethoxy-4-methylthiophenethylamine) is a psychedelic phenethylamine of the 2C series first described by Alexander Shulgin in PiHKAL. It is the parent sulfur-substituted 2C compound, related to 2C-T-2 and 2C-T-7. Human data is limited to self-experiments and anecdotal reports; there are no controlled studies.
01 Overview
2C-T is the base 4-methylthio member of the 2C-T subgroup, a family of sulfur-containing phenethylamine psychedelics. It acts as a serotonin 5-HT2A/2C agonist and is taken orally, with effects Shulgin described as moderate in intensity and duration relative to some of its longer-acting relatives.
As with the wider 2C-T subgroup, human knowledge derives almost entirely from PiHKAL and scattered user reports. The sulfur-substituted 2C-T compounds as a group carry additional caution because some members interact dangerously with monoamine oxidase inhibitors and a few (notably 2C-T-7) have been linked to fatalities; specific toxicology for 2C-T itself is essentially uncharacterised.
02 Mechanism
Agonist at serotonin 5-HT2A receptors (with 5-HT2C activity), the shared mechanism of classical serotonergic psychedelics.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 30–50 mg | Oral | Onset of noticeable effects; sensitivity varies. |
| Common | 60–100 mg | Oral | Range reported in PiHKAL; not clinically validated. |
| Strong | 100–150 mg | Oral | Higher doses increase intensity and risk; poorly characterised. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Visual distortionColour enhancement and visual patterning reported by users. | moderate | Anecdotal | |
| Altered mood and cognitionEmotional and cognitive shifts typical of serotonergic psychedelics. | Anecdotal | ||
| Body load and tactile enhancementPhysical sensations and tactile changes commonly reported with 2C-T compounds. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Nausea and body loadGastrointestinal discomfort and heavy body load reported during onset, a hallmark of the 2C-T subgroup. | Moderate | Common | Anecdotal | |
| Anxiety and confusionOverwhelming or frightening experiences, especially with unexpected potency. | Moderate | Common at higher doses | Anecdotal | |
| MAOI interaction riskSulfur-substituted 2C-T compounds are reported to interact dangerously with monoamine oxidase inhibitors, risking hypertensive or serotonergic crisis. | Life-threatening | Rare but severe | Anecdotal |