2C-N
2C-N is the 4-nitro member of the 2C phenethylamine family. Shulgin reported it as weakly active with a muted, largely uninteresting profile, and it remains among the least-used and least-studied 2C compounds.
01 Overview
2C-N (2,5-dimethoxy-4-nitrophenethylamine) was characterised by Alexander Shulgin, who found only mild effects at relatively high doses. The nitro group appears to blunt potency compared with halogen- or thioether-substituted 2C analogues.
Human exposure is rare and no clinical or toxicological studies exist. Any characterisation is anecdotal and the nitroaromatic moiety raises unquantified toxicity concerns.
02 Mechanism
Partial agonist at 5-HT2A/2C receptors; the electron-withdrawing 4-nitro substituent reduces binding potency relative to other 2C-x compounds.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Reported active | 100–150 mg | Oral | Shulgin range; effects described as weak. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Mild mood liftFaint, short-lived shift in mood without strong visual character. | slight | Anecdotal | |
| Weak sensory changeSubtle perceptual shifts reported as far weaker than 2C-B. | minimal | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaStomach discomfort typical of the 2C class. | Mild | Common | Anecdotal | |
| Nitroaromatic toxicity concernNitro-substituted aromatics can raise oxidative/metabolic toxicity questions; unstudied here. | Moderate | Unknown | Unconfirmed |