25TFM-NBOMe
25TFM-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-TFM (4-trifluoromethyl-2C). It is a potent NBOMe-class 5-HT2A agonist psychedelic, orally inactive and sub-milligram active, sharing the family's narrow margin, vasoconstriction and seizure risk.
01 Overview
25TFM-NBOMe carries a 4-trifluoromethyl group on the phenethylamine ring plus the NBOMe modification. It is a rare research chemical with no controlled human study.
Information is anecdotal. The trifluoromethyl group tends to confer high 5-HT2A affinity and metabolic stability, so the compound is expected to be potent and comparatively long-acting, with full NBOMe class toxicity.
02 Mechanism
Potent agonist at serotonin 5-HT2A receptors; the 4-CF3 ring group and N-2-methoxybenzyl substituent together produce high 5-HT2A affinity and potency.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 100–300 µg | Sublingual | Estimated; potent. |
| Common | 300–1000 µg | Sublingual | Anecdotal only. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psychedelic effectsStrong visuals and cognitive alteration expected from a high-affinity NBOMe. | 8-12 h | Anecdotal | |
| StimulationBody load, tension and insomnia. | marked | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Severe vasoconstrictionCold, painful extremities with hypertension and tachycardia. | Severe | Common | Anecdotal | |
| Seizures and hyperthermiaOverdose can cause agitation, seizures, hyperthermia and rhabdomyolysis. | Life-threatening | Uncommon | Anecdotal |