25T2-NBOMe
25T2-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-T-2, a sulphur-containing phenethylamine psychedelic. It is a potent 5-HT2A agonist of the NBOMe class, orally inactive and sub-milligram active, sharing the family's steep dose-response, vasoconstriction and seizure risks.
01 Overview
25T2-NBOMe applies the NBOMe modification to the thioether 2C-T-2 scaffold. It is an obscure compound with very limited market presence and no controlled human study.
Information is anecdotal and analytical only. The thioether group adds metabolic and pharmacological uncertainty on top of the already hazardous NBOMe profile, and the compound carries the full class risk of cardiovascular and neurological toxicity.
02 Mechanism
Potent agonist at serotonin 5-HT2A receptors; the N-2-methoxybenzyl substituent markedly increases 5-HT2A affinity of the 2C-T-2 backbone.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 200–500 µg | Sublingual | Estimated; almost no data. |
| Common | 500–1500 µg | Sublingual | Anecdotal only. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psychedelic effectsVisuals and cognitive alteration consistent with the NBOMe series. | 6-10 h | Anecdotal | |
| Stimulation and body loadTension, tremor and restlessness; nausea may be prominent given the thioether parent. | moderate-marked | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| VasoconstrictionCold extremities, hypertension and tachycardia. | Severe | Common | Anecdotal | |
| Seizures and serotonergic toxicityOverdose can cause agitation, seizures and hyperthermia as with other NBOMes. | Life-threatening | Uncommon | Anecdotal |