25P-NBOMe
25P-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-P, one of the more potent 2C compounds. It is a strong, long-acting 5-HT2A agonist psychedelic active in the microgram range, orally inactive, and carries the NBOMe class hazards of narrow margin, vasoconstriction and seizures.
01 Overview
25P-NBOMe combines the potent 2C-P scaffold with the NBOMe modification, producing a very potent and unusually long-lasting psychedelic. It has been sold as blotter and detected in forensic samples.
Human information is anecdotal, and the very long duration (often reported at 10-16 hours) raises the risk of anxious redosing and prolonged cardiovascular strain. Class toxicity — vasoconstriction, agitation, seizures — applies fully.
02 Mechanism
Potent, high-efficacy agonist at 5-HT2A receptors; the N-2-methoxybenzyl group amplifies the already high 5-HT2A affinity of the 2C-P backbone.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 100–300 µg | Sublingual | Very potent; estimated. |
| Common | 300–900 µg | Sublingual | Anecdotal; very long duration. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Prolonged psychedelic experienceIntense, long-lasting visuals and cognitive alteration, among the longest of the NBOMe series. | 10-16 h | Anecdotal | |
| StimulationStrong body load, tension and insomnia. | marked | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Severe vasoconstrictionCold, painful extremities and sustained hypertension over the long duration. | Severe | Common | Anecdotal | |
| Anxiety, agitation and seizuresLong duration can produce escalating anxiety, panic and, at high doses, seizures. | Severe | Uncommon | Anecdotal |