25N-NBOMe
25N-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-N, bearing a 4-nitro group on the phenethylamine ring. It is a potent 5-HT2A agonist psychedelic of the NBOMe class, orally inactive and sub-milligram active, with the same narrow safety margin, vasoconstriction and seizure hazards.
01 Overview
25N-NBOMe is a rare member of the 25x-NBOMe series distinguished by its 4-nitro ring substituent. It has appeared occasionally on blotter research-chemical markets and in seized samples.
There are essentially no controlled human data; information is anecdotal and forensic. The nitro substitution and NBOMe modification give a potent, long-acting psychedelic that shares the class hazards, and the compound has been implicated in acute toxicity presentations.
02 Mechanism
Potent agonist at serotonin 5-HT2A receptors; N-2-methoxybenzyl substitution of 2C-N sharply increases 5-HT2A affinity relative to the parent.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 200–500 µg | Sublingual | Estimated; very sparse data. |
| Common | 500–1500 µg | Sublingual | Anecdotal; long duration. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psychedelic effectsVisuals and altered cognition consistent with the 25x-NBOMe family. | 6-10 h | Anecdotal | |
| StimulationBody load, tension and restlessness. | marked | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| VasoconstrictionCold, painful extremities with hypertension and tachycardia. | Severe | Common | Anecdotal | |
| Seizures and hyperthermiaOverdose can cause agitation, seizures, hyperthermia and rhabdomyolysis. | Life-threatening | Uncommon | Anecdotal |