25I-NBMD
25I-NBMD is the N-(2,3-methylenedioxybenzyl) derivative of 2C-I, a rare NBMD-series N-benzyl phenethylamine psychedelic. It is a potent 5-HT2A agonist that shares the 25x family's narrow safety margin, marked vasoconstriction and seizure risk.
01 Overview
25I-NBMD replaces the NBOMe 2-methoxybenzyl group with a 2,3-methylenedioxybenzyl group on the widely-studied 2C-I scaffold. It has been characterised in research settings and appears only rarely on the market.
Human information is anecdotal and analytical. Given the potent 2C-I backbone and N-benzyl modification, it is expected to be highly potent, with the full class hazards of vasoconstriction and serotonergic overstimulation and the documented NBOMe-family risk of fatal overdose from dosing errors.
02 Mechanism
Potent agonist at serotonin 5-HT2A receptors; the N-2,3-methylenedioxybenzyl group confers high 5-HT2A affinity on the potent 2C-I scaffold.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 150–400 µg | Sublingual | Estimated; potent scaffold. |
| Common | 400–1200 µg | Sublingual | Anecdotal only. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psychedelic effectsStrong visuals and cognitive alteration expected from a potent 25x-NB compound. | 6-10 h | Anecdotal | |
| StimulationBody load, tension and insomnia. | marked | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Severe vasoconstrictionCold, painful extremities with hypertension and tachycardia. | Severe | Common | Anecdotal | |
| Seizures and hyperthermiaOverdose can cause agitation, seizures, hyperthermia and rhabdomyolysis, as documented across the NBOMe family. | Life-threatening | Uncommon | Anecdotal |