25G-NBOMe
25G-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-G (a dimethyl-substituted phenethylamine). It is a potent NBOMe-class 5-HT2A agonist psychedelic, orally inactive and sub-milligram active, with the family's narrow safety margin, vasoconstriction and seizure hazards.
01 Overview
25G-NBOMe is a rare 25x-NBOMe compound derived from the 2C-G family of ring-methylated phenethylamines. It has minimal market presence and no controlled human data.
Available information is anecdotal and analytical. As with all NBOMes, the sub-milligram active range and steep dose-response mean small dosing errors can produce severe cardiovascular and neurological toxicity.
02 Mechanism
Potent agonist at 5-HT2A receptors; N-2-methoxybenzyl substitution increases 5-HT2A affinity of the 2C-G scaffold by orders of magnitude.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 200–500 µg | Sublingual | Estimated; sparse data. |
| Common | 500–1500 µg | Sublingual | Anecdotal only. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psychedelic effectsVisuals and altered cognition; 2C-G parent is associated with long duration. | 6-12 h | Anecdotal | |
| StimulationBody load and tension typical of the NBOMe series. | moderate | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| VasoconstrictionCold extremities, hypertension and tachycardia. | Severe | Common | Anecdotal | |
| Seizures and hyperthermiaOverdose can cause agitation, seizures and hyperthermia as in the class. | Life-threatening | Uncommon | Anecdotal |