25D-NBOH
25D-NBOH is the N-(2-hydroxybenzyl) derivative of 2C-D, part of the NBOH series of potent 5-HT2A agonist psychedelics. It is orally inactive, taken sublingually, and shares the narrow safety margin, vasoconstriction and seizure risk characteristic of N-benzyl phenethylamines.
01 Overview
25D-NBOH is a little-known NBOH compound derived from 2C-D. NBOH substances substitute a 2-hydroxybenzyl for the NBOMe 2-methoxybenzyl group and are marketed similarly on blotter.
There are no controlled human data; information is anecdotal. Despite occasional framing as gentler than NBOMe, 25D-NBOH retains the class's steep dose-response and cardiovascular/neurological toxicity.
02 Mechanism
Potent agonist at serotonin 5-HT2A receptors; the N-2-hydroxybenzyl group confers high 5-HT2A affinity on the 2C-D scaffold.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 300–700 µg | Sublingual | Estimated; sparse data. |
| Common | 700–2000 µg | Sublingual | Anecdotal only. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psychedelic effectsVisuals and altered cognition consistent with the NBOH family. | 5-9 h | Anecdotal | |
| StimulationBody load and tension. | moderate | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| VasoconstrictionCold extremities and hypertension. | Severe | Common | Anecdotal | |
| Seizures and serotonergic toxicityOverdose can cause agitation, seizures and hyperthermia. | Life-threatening | Uncommon | Anecdotal |