25C-NBOMe
25C-NBOMe (2C-C-NBOMe) is an extremely potent N-benzyl psychedelic closely related to 25I-NBOMe. It is active in the microgram range, taken sublingually, and shares the same dangerous profile: a narrow margin of safety with seizures, severe vasoconstriction, hyperthermia and deaths. It is frequently mis-sold as LSD. Human data come mainly from toxicology case reports.
01 Overview
25C-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-C and, like 25I-NBOMe, is a highly potent 5-HT2A agonist active at microgram doses when taken sublingually. It is commonly distributed on blotter and mis-sold as LSD, making accurate dosing effectively impossible.
Its toxicity mirrors the wider NBOMe series: the margin between an active and a life-threatening dose is narrow, and case reports describe generalised seizures, severe hypertension and vasoconstriction, agitation, hyperthermia and cardiac collapse, with confirmed fatalities. As with 25I-NBOMe, this differs fundamentally from the wide safety margin of classical psychedelics and is stated plainly.
02 Mechanism
Extremely potent agonist at serotonin 5-HT2A receptors; the N-benzyl substitution greatly increases potency over the parent 2C-C.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 50–100 mcg | Sublingual | Active in micrograms; blotter distribution prevents accurate dosing. |
| Common | 200–700 mcg | Sublingual | Narrow margin; toxicity reported near recreational doses. |
| Strong | 700–1000 mcg | Sublingual | High risk of seizures and cardiovascular collapse. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Intense visual psychedeliaStrong visual effects reported at active doses. | strong | Anecdotal | |
| StimulationStimulant character similar to other NBOMe compounds. | Anecdotal | ||
| Metallic taste and body loadBitter/metallic taste and physical discomfort commonly reported. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Hyperthermia and agitationExtreme agitation with hyperthermia risking rhabdomyolysis and organ injury. | Severe | Reported in severe cases | Observational | |
| SeizuresGeneralised seizures feature prominently in NBOMe toxicity case reports. | Life-threatening | Common in toxicity presentations | Observational | |
| Severe vasoconstriction and cardiac eventsSevere hypertension, tachycardia, vasoconstriction and cardiac collapse have caused deaths. | Life-threatening | Common in toxicity presentations | Observational |