25C-NBF
25C-NBF is the N-(2-fluorobenzyl) derivative of 2C-C, part of the NBF series of N-benzyl phenethylamine psychedelics. It is a potent 5-HT2A agonist active in the sub-milligram range and shares the narrow safety margin, vasoconstriction and seizure risk of the broader 25x family.
01 Overview
25C-NBF belongs to the NBF subfamily, in which the N-benzyl group bears a 2-fluoro substituent instead of the 2-methoxy of NBOMe. It has appeared on blotter research-chemical markets and in seized samples.
Human data are anecdotal only. NBF compounds are broadly comparable in potency and risk to NBOMes, and 25C-NBF carries the full class hazards of vasoconstriction and serotonergic overstimulation.
02 Mechanism
Potent agonist at serotonin 5-HT2A receptors; the N-2-fluorobenzyl group confers high 5-HT2A affinity on the 2C-C scaffold.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 200–500 µg | Sublingual | Estimated; sparse data. |
| Common | 500–1500 µg | Sublingual | Anecdotal only. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psychedelic effectsVisuals and cognitive alteration consistent with the 25x class. | 6-10 h | Anecdotal | |
| StimulationBody load, tension and restlessness. | marked | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| VasoconstrictionCold, painful extremities with hypertension and tachycardia. | Severe | Common | Anecdotal | |
| Seizures and hyperthermiaOverdose can cause agitation, seizures, hyperthermia and rhabdomyolysis. | Life-threatening | Uncommon | Anecdotal |