25B-NBMD
25B-NBMD is the N-(2,3-methylenedioxybenzyl) derivative of 2C-B, a rare member of the NBMD subfamily of N-benzyl phenethylamine psychedelics. It is a potent 5-HT2A agonist sharing the 25x family's narrow safety margin, vasoconstriction and seizure risk.
01 Overview
25B-NBMD substitutes a 2,3-methylenedioxybenzyl group for the NBOMe 2-methoxybenzyl. It is an obscure compound that has been characterised chemically and appears only rarely in the market.
Human data are essentially nonexistent; information is anecdotal and analytical. As with all N-benzyl phenethylamines, the sub-milligram active range and steep dose-response make dosing errors dangerous, and the class hazards of vasoconstriction and serotonergic overstimulation apply.
02 Mechanism
Potent agonist at serotonin 5-HT2A receptors; the N-2,3-methylenedioxybenzyl group confers high 5-HT2A affinity on the 2C-B scaffold.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 200–500 µg | Sublingual | Estimated; almost no data. |
| Common | 500–1500 µg | Sublingual | Anecdotal only. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psychedelic effectsVisuals and cognitive alteration consistent with the 25x-NB class. | 6-10 h | Anecdotal | |
| StimulationBody load and tension. | moderate | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| VasoconstrictionCold extremities and hypertension. | Severe | Common | Anecdotal | |
| Seizures and serotonergic toxicityOverdose can cause agitation, seizures and hyperthermia. | Life-threatening | Uncommon | Anecdotal |