2-CMC
2-CMC (2-chloromethcathinone, clophedrone) is a synthetic cathinone stimulant, the ortho-chloro isomer of the halogenated methcathinone series that includes 4-CMC. It circulated widely as a research chemical after mephedrone bans. Human pharmacology is uncharacterised; reported effects are anecdotal and describe a stimulating, functional profile with a strong redose pull.
01 Overview
2-CMC is a ring-chlorinated cathinone sold as a 'research chemical' with no approved medical use. The chlorine at the ortho position distinguishes it from the more common 4-CMC; users describe a stimulating, somewhat functional character with limited euphoria and a marked urge to redose.
The class hazards apply in full: compulsive redosing, cardiovascular strain, harsh comedown and unknown neurotoxicity. There are no controlled human studies, so figures are approximate and drawn from user reports.
02 Mechanism
Presumed monoamine releaser and reuptake inhibitor at dopamine, noradrenaline and serotonin transporters, in the halogenated methcathinone series.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Common | 50–150 mg | Insufflated | Faster onset, more compulsive. |
| Common | 100–250 mg | Oral | Anecdotal only. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| StimulationEnergy and alertness reported by users. | Anecdotal | ||
| Increased focusFunctional, task-oriented stimulation reported. | Anecdotal | ||
| Appetite suppressionReduced hunger during effects. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Compulsive redosingUrge to redose repeatedly, driving binges. | Moderate | Most users | Anecdotal | |
| Cardiovascular strainTachycardia and hypertension typical of the class. | Severe | Common | Unconfirmed | |
| InsomniaDifficulty sleeping for hours after use. | Mild | Common | Anecdotal |