19-Nor-DHEA
19-Nor-DHEA (19-nor-androst-4-ene-3β-ol,17-one) is a non-methylated prohormone that converts to nandrolone (19-nortestosterone). Marketed for lean-mass gains, it carries nandrolone's progestogenic risk profile — potential libido loss and mood effects — with efficacy resting entirely on anecdote.
01 Overview
19-Nor-DHEA is a prohormone designed to yield nandrolone in the body via 3β-HSD and 17β-HSD conversion. Because the active hormone is 19-nortestosterone, users expect nandrolone-like effects: steady lean-mass accrual, joint-comfort reports, and relatively low aromatisation, but with the progestogenic activity characteristic of 19-nor compounds. It was a common ingredient in early-2010s 'bulking' prohormone stacks.
There are no controlled human efficacy studies of the prohormone itself; its rationale is inferred from the well-studied pharmacology of nandrolone plus user reports. It converts inefficiently and suppresses the HPTA. The 19-nor structure raises concern for progestogenic side effects such as reduced libido ('deca dick') and prolactin-related issues even though the parent is a prohormone.
02 Mechanism
Converts to nandrolone (19-nortestosterone), a mildly aromatising anabolic androgen with progestogenic activity that binds the androgen and progesterone receptors.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Common (marketed) | 100–400 mg/day | Oral | Labelled supplement dosing, typically split through the day. |
Ester comparison
| Ester | Half-life | Injection freq. | Testosterone by mass |
|---|
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Lean mass gainNandrolone-like steady gains reported over longer 6-8 week runs. | slow, steady | Anecdotal | |
| Joint comfortUsers report improved joint comfort, a hallmark associated with nandrolone. | subjective | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Progestogenic libido lossReduced libido and erectile difficulty ('deca dick') reported, linked to progestogenic activity. | Moderate | Common | Anecdotal | |
| HPTA suppressionMeaningful testosterone suppression requiring recovery support. | Moderate | Near-universal | Anecdotal |