1-Testosterone Cypionate (DHB Cypionate)
An injectable cypionate ester of 1-testosterone (dihydroboldenone, DHB), a highly anabolic non-aromatising steroid structurally related to boldenone but 5-alpha reduced. It is valued for lean, dry gains and a strong anabolic-to-androgenic ratio, but is notorious for severe, prolonged post-injection pain that limits its practical use. Human evidence is essentially anecdotal.
01 Overview
1-Testosterone is 1(5-alpha)-androsten-17-beta-ol-3-one — effectively the 5-alpha reduced form of boldenone, or dihydroboldenone (DHB). The cypionate ester gives a medium-length release. The compound does not aromatise and is already 5-alpha reduced, so it produces no oestrogen and its androgenic activity does not amplify in tissues like scalp and prostate the way testosterone's does.
DHB is reputed for high-quality lean mass with minimal water retention and a favourable anabolic profile, but the overwhelming practical complaint is intense, lingering injection-site pain and inflammation, which makes consistent dosing difficult. Its evidence base is anecdotal and inferred from the parent DHB pharmacology; there are no meaningful human clinical studies.
02 Mechanism
Potent androgen-receptor agonist increasing protein synthesis; being 5-alpha reduced it does not aromatise and has no progestogenic activity, giving dry, non-oestrogenic gains.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Common | 200–400 mg/wk | IM | Injection-site pain often limits practical dosing. |
| Heavy | 400–500 mg/wk | IM | Pain and inflammation typically worsen with volume. |
Ester comparison
| Ester | Half-life | Injection freq. | Testosterone by mass |
|---|
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Lean, dry muscle gainReported high-quality lean gains with little water retention; no controlled human data. | Anecdotal | ||
| No oestrogenic activityDoes not aromatise, avoiding oestrogenic water retention and gynaecomastia. | Preclinical | ||
| Strong anabolic-to-androgenic ratioHigh anabolic potency relative to androgenicity, inferred from DHB pharmacology. | Preclinical |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Androgenic effectsAcne, oily skin and possible hair thinning in predisposed users. | Mild | Common | Anecdotal | |
| Severe post-injection painIntense, prolonged injection-site pain and swelling that frequently limits use. | Moderate | Very common | Anecdotal | |
| HPTA suppressionSuppresses endogenous testosterone and gonadotropins. | Severe | Universal | Observational |