1-DHEA (1-Androsterone precursor)
A popular post-2014-scheduling-era prohormone that converts to 1-androsterone and ultimately 1-testosterone, a non-aromatising DHT-derived androgen. Prized in the community for 'dry' lean gains without estrogen conversion, but suppressive and unstudied in humans. DASCA-scheduled in the US.
01 Overview
1-DHEA (1-androstene-3-beta-ol-17-one) is a 1-ene DHEA analog whose active downstream metabolite is 1-testosterone (dihydroboldenone), a potent non-aromatising androgen derived from the DHT structural class. It became one of the most widely sold prohormones after the first prohormone bans.
Because the end product cannot aromatise, users report lean, 'dry' gains with reduced water retention, at the cost of DHT-type side effects and notable suppression. There are essentially no controlled human trials; the profile is inferred from 1-testosterone pharmacology and user reports. It is listed as a controlled anabolic steroid.
02 Mechanism
Converted via 3-beta-HSD and 17-beta-HSD to 1-androsterone and then 1-testosterone (dihydroboldenone), a non-aromatising, 5-alpha-reductase-resistant androgen.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Community-typical | 100–330 mg/day | Oral | Reported prohormone dosing; not medically validated. |
Ester comparison
| Ester | Half-life | Injection freq. | Testosterone by mass |
|---|
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Dry lean mass and strength gainsUsers report steady lean gains without water retention; no controlled human data exist. | ~2-4 kg lean over a cycle (reported) | Anecdotal | |
| No estrogen conversion1-testosterone does not aromatise, so estrogenic side effects are absent. | Non-aromatising | Preclinical |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Lethargy and reduced enduranceFatigue and cardiovascular endurance drop are frequently reported on 1-testosterone precursors. | Moderate | Commonly reported | Anecdotal | |
| HPTA suppressionMarked suppression of endogenous testosterone requiring recovery support. | Moderate | Near-universal | Anecdotal |